Case report of fatal Mycobacterium tilburgii infection.

Autor: Akpinar T; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address: timurselcukapinar@gmail.com., Bakkaloglu OK; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Ince B; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Tufan F; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Kose M; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Poda M; Dept. of Genetics, DETAE, Istanbul University, Istanbul, Turkey., Tascioglu D; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Koksalan OK; Mol. TB. Epi. Lab., DETAE, Istanbul University, Istanbul, Turkey., Saka B; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Erten N; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Buyukbabani N; Dept. of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Kilicaslan Z; Dept. of Chest Diseases and Tuberculosis, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey., Tascioglu C; Dept. of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2015 Jul; Vol. 21 (7), pp. 538-40. Date of Electronic Publication: 2015 Feb 24.
DOI: 10.1016/j.jiac.2015.02.006
Abstrakt: There are few reports concerning Mycobacterium tilburgii infection in humans because this bacterium is non-cultivatable. Herein, using new molecular techniques, we report the case of an immunocompromised patient with fatal disseminated lymphadenitis that was caused by M. tilburgii.26 years old Caucasian HIV negative female patient presented with abdominal pain. Her clinical assessment revealed disseminated lymphadenitis, that was acid fast bacilli positive. Further molecular evaluation showed the causative agent as M. tilburgii. Despite anti mycobacterial therapy and careful management of intervening complications patient died because of an intraabdominal sepsis. This is the first fatal M. tilburgii infection in the literature. This case points the importance of careful management of patient's immune status and intervening infections besides implementation of effective drug treatment.
(Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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