In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract.

Autor: Dyary HO; Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; College of Veterinary Medicine, University of Sulaimani, Iraq., Arifah AK; Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: arifah@upm.edu.my., Sharma RS; Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Rasedee A; Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Mohd Aspollah MS; Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Zakaria ZA; Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Zuraini A; Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Somchit MN; Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2015 Jun; Vol. 100, pp. 226-31. Date of Electronic Publication: 2015 Mar 06.
DOI: 10.1016/j.rvsc.2015.03.007
Abstrakt: The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague-Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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