Memory formation and retention are affected in adult miR-132/212 knockout mice.

Autor: Hernandez-Rapp J; Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada., Smith PY; Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada., Filali M; Plateforme d'analyse fonctionnelle du comportement animal, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada., Goupil C; Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada., Planel E; Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada., Magill ST; Vollum Institute, Oregon Health and Science University, Portland, USA., Goodman RH; Vollum Institute, Oregon Health and Science University, Portland, USA., Hébert SS; Axe Neurosciences, Centre de recherche du CHU de Québec, CHUL, Québec, QC, Canada; Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada. Electronic address: sebastien.hebert@neurosciences.ulaval.ca.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2015; Vol. 287, pp. 15-26. Date of Electronic Publication: 2015 Mar 23.
DOI: 10.1016/j.bbr.2015.03.032
Abstrakt: The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and non-cognitive behavioral tests. No significant changes were observed in reflexes and basic sensorimotor functions as determined by the SHIRPA primary screen. Accordingly, miR-132/212 knockout mice did not differ from wild-type controls in general locomotor activity in an open-field test. Furthermore, no significant changes of anxiety were measured in an elevated plus maze task. However, the mutant mice showed retention phase defects in a novel object recognition test and in the T-water maze. Moreover, the learning and probe phases in the Barnes maze were clearly altered in knockout mice when compared to controls. Finally, changes in BDNF, CREB, and MeCP2 were identified in the miR-132/212-deficient mice, providing a potential mechanism for promoting memory loss. Taken together, these results further strengthen the role of miR-132/212 in memory formation and retention, and shed light on the potential consequences of its deregulation in neurodegenerative diseases.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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