Health related quality of life and perception of stigmatisation in adolescents living with sickle cell disease in Nigeria: A cross sectional study.

Autor: Adeyemo TA; Department of Haematology & Blood Transfusion, College of Medicine, University of Lagos & Lagos University Teaching Hospital, Lagos, Nigeria., Ojewunmi OO; Sickle Cell Foundation Nigeria, Lagos, Nigeria., Diaku-Akinwumi IN; Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Ayinde OC; Department of Biomedical Sciences, Aston University, Birmingham, United Kingdom., Akanmu AS; Department of Haematology & Blood Transfusion, College of Medicine, University of Lagos & Lagos University Teaching Hospital, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2015 Jul; Vol. 62 (7), pp. 1245-51. Date of Electronic Publication: 2015 Mar 25.
DOI: 10.1002/pbc.25503
Abstrakt: Background: Sickle cell disease impacts the physical, emotional and psychological aspects of life of the affected persons, often times exposing them to disease associated stigma from the society and alters the health related quality of life (HRQoL). This study compared the HRQoL of adolescents with sickle cell disease with their healthy peers, identified socio-demographic and clinical factors impacting HRQoL, and determined the extent and effects of SCD related stigma on quality of life.
Procedure: We conducted a cross-sectional survey among 160 adolescents, 80 with SCD and 80 adolescents without SCD. Socio-demographic and clinical data were collected using a pre-tested questionnaire. HRQoL was investigated using the Short Form (SF-36v2) Health Survey. SCD perceived stigma was measured using an adaptation of a perceived stigma questionnaire.
Results: Adolescents with SCD have significantly worse HRQoL than their peers in all of the most important dimensions of HRQoL (physical functioning, physical roles limitation, emotional roles limitation, social functioning, bodily pain, vitality and general health perception) except mental health. Recent hospital admission and SCD related complication further lowered HRQoL scores. Over seventy percent of adolescents with SCD have moderate to high level of perception of stigmatisation. Hospitalisation, SCD complication, SCD stigma were inversely, and significantly associated with HRQoL.
Conclusions: Adolescents living with SCD in Nigeria have lower health related quality of life compared to their healthy peers. They also experience stigma that impacts their HRQoL. Complications of SCD and hospital admissions contribute significantly to this impairment.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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