| Autor: |
Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, CB #7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA. mkakoki@med.unc.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Current hypertension reviews [Curr Hypertens Rev] 2014; Vol. 10 (4), pp. 223-38. |
| DOI: |
10.2174/157340211004150319123313 |
| Abstrakt: |
Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) β1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFβ1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFβ1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFβ signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFβ1 could influence blood pressure levels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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