| Autor: |
Issa JP; School of Dentistry of Ribeirao Preto, University of Sao Paulo , Ribeirao Preto, Sao Paulo , Brazil and., Ingraci de Lucia C, Dos Santos Kotake BG, Gonçalves Gonzaga M, Tocchini de Figueiredo FA, Mizusaki Iyomasa D, Macedo AP, Ervolino E |
| Jazyk: |
angličtina |
| Zdroj: |
Growth factors (Chur, Switzerland) [Growth Factors] 2015 Apr; Vol. 33 (2), pp. 139-48. Date of Electronic Publication: 2015 Mar 23. |
| DOI: |
10.3109/08977194.2015.1011270 |
| Abstrakt: |
The aim of this research was to evaluate the fracture healing area in osteoporotic femur of female rats restrained by stainless steel wire by statin administration in two different doses (5 mg and 20 mg). Ninety female rats were divided into six groups (n = 15): SH, SH-5 mg, SH-20 mg, OVX, OVX-5 mg, and OVX-20 mg. The surgery consisted of the fracture of the left femur bone and stabilization by K-wire and the administration was restricted and weekly controlled in the drinking water. The euthanasia was conducted at three different moments, five animals per period: 7 d, 14 d, and 28 d. Densitometry, zymography, and histological analyses showed a significant difference between some groups. According to these findings, simvastatin promoted a positive action for bone repair, especially in the osteometabolic group treated with 20 mg of the drug. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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