Targeting dengue virus NS4B protein for drug discovery.

Autor: Xie X; Novartis Institute for Tropical Diseases, Singapore., Zou J; Novartis Institute for Tropical Diseases, Singapore; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing, China., Wang QY; Novartis Institute for Tropical Diseases, Singapore. Electronic address: qing_yin.wang@novartis.com., Shi PY; Novartis Institute for Tropical Diseases, Singapore. Electronic address: pei_yong.shi@novartis.com.
Jazyk: angličtina
Zdroj: Antiviral research [Antiviral Res] 2015 Jun; Vol. 118, pp. 39-45. Date of Electronic Publication: 2015 Mar 19.
DOI: 10.1016/j.antiviral.2015.03.007
Abstrakt: The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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