Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.

Autor:	Eslami Amirabadi MR; Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Rajezi Esfahani S; Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Davari-Ashtiani R; Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Khademi M; Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Emamalizadeh B; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Movafagh A; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Sadr S; Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Arabgol F; Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran., Darvish H; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Razjoyan K; Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Jazyk:	angličtina
Zdroj:	Iranian Red Crescent medical journal [Iran Red Crescent Med J] 2015 Feb 21; Vol. 17 (2), pp. e23095. Date of Electronic Publication: 2015 Feb 21 (Print Publication: 2015).
DOI:	10.5812/ircmj.23095
Abstrakt:	Background: Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies. Objectives: This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population. Patients and Methods: This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene. Results: Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder. Conclusions: The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.
Databáze:	MEDLINE
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