D-dimer and international normalized ratio (INR) are correlated with tumor markers and disease stage in colorectal cancer patients.

Autor: Kilic L; Medical Oncology Department, Firat University Hospital, Elazig, Turkey., Yildiz I; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Sen FK; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Erdem MG; Agri Hamur State Hospital, Internal Medicine Clinic, Hamur, Agri, Turkey., Serilmez M; Biochemistry Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Keskin S; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Ciftci R; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Karabulut S; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Ordu C; Medical Oncology Department, Bedii Gorbon Oncology Center, Avrupa Florence Nightingale Hospital, Sisli, Istanbul, Turkey., Duranyildiz D; Biochemistry Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey., Tas F; Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2015; Vol. 15 (4), pp. 405-11.
DOI: 10.3233/CBM-150477
Abstrakt: Background: The aim of this study is to evaluate the correlation of coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients.
Materials and Methods: Ninety-four CRC patients were included for evaluation of clinicopathological factors, coagulation assays and tumor marker levels.
Results: Metastatic disease was related with elevated INR (p= 0.03). Stage III patients had higher D-dimer values compared with stage II patients (p= 0.03). Correlation of tumor markers indicated a tendency towards elevated D-dimer levels for CEA values higher than median (p= 0.01). High CA 19-9 levels were also associated with higher INR (p= 0.007). Elderly age, distant metastasis, high CEA, CA-19-9 and LDH levels were associated with poorer overall-survival. CEA level was the only independent prognostic factor in multivariate analysis.
Conclusions: Coagulation assays can be utilized as predictors of disease extent in CRC. Elevated D-dimer and INR values may indicate higher disease stage. Correlation of D-dimer levels with CEA supports their value for assessing tumor burden.
Databáze: MEDLINE
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