Obesity and the use of antibiotics and probiotics in rats.
| Autor: | de Sá Del Fiol F; Department of Pharmacology, University of Sorocaba, Sorocaba, Brazil., Tardelli Ferreira AC, Marciano JJ, Marques MC, Sant'Ana LL |
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| Jazyk: | angličtina |
| Zdroj: | Chemotherapy [Chemotherapy] 2014; Vol. 60 (3), pp. 162-7. Date of Electronic Publication: 2015 Mar 18. |
| DOI: | 10.1159/000371737 |
| Abstrakt: | Background: Obesity has become a major public health challenge in recent years. Recent studies suggest that alterations of the gut microbiota by antibiotics could play an important role in obesity. Methods: We investigated this topic using 60 Wistar rats, which were divided into 3 experimental groups: rats treated with amoxicillin, rats treated with amoxicillin plus Saccharomyces boulardii and controls. Treatments were administered over the course of 2 weeks. Tetrapolar bioelectric impedance analysis and anthropometric evaluations were conducted. Results: The body mass index was significantly lower for the animals in the control group (p = 0.034). The same result was observed for the Lee index: the control group had a lower index than the 2 groups that received antibiotic treatment (p = 0.0019). The total body water data demonstrated that the control group had the greatest amount of body water (279.1 g, p = 0.0243). Conclusions: The groups treated with the antibiotic exhibited a greater accumulation of body fat than the control group. |
| Databáze: | MEDLINE |
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