Implication of corticotropic hormone axis in eating behaviour pattern in obese and type 2 diabetic participants.

Autor: Benbaibeche H; Laboratoire de Bioénergétique et Métabolisme Intermédiaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene,Alger,Algérie., Haffaf el M; Service de Médecine Nucléaire, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie., Kacimi G; Laboratoire de Biochimie, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie., Oudjit B; Service de Diabétologie, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie., Khan NA; Physiologie de la Nutrition & Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup,6 Boulevard Gabriel,Dijon21000,France., Koceïr EA; Laboratoire de Bioénergétique et Métabolisme Intermédiaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene,Alger,Algérie.
Jazyk: angličtina
Zdroj: The British journal of nutrition [Br J Nutr] 2015 Apr 28; Vol. 113 (8), pp. 1237-43. Date of Electronic Publication: 2015 Mar 18.
DOI: 10.1017/S0007114515000549
Abstrakt: In Algeria, eating behaviour has been increasingly deviated from its traditional Mediterranean diet to modern fast food style. The present study examines the interactions between eating behaviour pattern (EBP), corticotropic hormone axis and the metabolic syndrome. Our Algerian population cohort comprised of 410 participants (130 obese, 170 type 2 diabetics and 110 healthy participants). The EBP was evaluated by the Three-Factor Eating Questionnaire test. The anthropometric and metabolic parameters (glucose, TAG, HDL, LDL and cholesterol) and the concentrations of hormones (insulin, adrenocorticotropin hormone (ACTH), cortisol and growth hormone) were determined by biometrics, spectrophotometry and RIA, respectively. Multivariate analyses showed a high correlation between the EBP and the metabolic syndrome, particularly between insulin-resistant state and hypertrophy of visceral adipose tissue. Compared with healthy participants, obese ones showed the hyperphagic type of EBP, i.e. disinhibition and hunger disorders. Conversely, the diabetics showed both the hypophagic and hyperphagic type of EBP. In diabetic and obese participants, cortisol and ACTH secretions were significantly altered, leading to metabolic disorders. The present study confirms the role of EBP in obesity and diabetes.
Databáze: MEDLINE