Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

Autor: Le TM; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands., van Hoffen E; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands ; Current affiliation: NIZO food research, Ede, The Netherlands., Kummeling I; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands ; Department of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK., Potts J; Department of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK., Ballmer-Weber BK; Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland., Bruijnzeel-Koomen CA; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands., Lebens AF; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands., Lidholm J; Thermo Fisher Scientific, Uppsala, Sweden., Lindner TM; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands., Mackie A; Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA UK., Mills EC; Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK., van Ree R; Department of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands., Vieths S; Division of Allergology, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany., Fernández-Rivas M; Allergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain., Burney PG; Department of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK., Knulst AC; Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Clinical and translational allergy [Clin Transl Allergy] 2015 Feb 25; Vol. 5, pp. 8. Date of Electronic Publication: 2015 Feb 25 (Print Publication: 2015).
DOI: 10.1186/s13601-015-0051-1
Abstrakt: Background: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.
Objective: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.
Methods: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.
Results: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.
Conclusion: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.
Databáze: MEDLINE
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