CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.

Autor:	Hickman HD; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address: hhickman@mail.nih.gov., Reynoso GV; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Ngudiankama BF; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Cush SS; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Gibbs J; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Bennink JR; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Yewdell JW; Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Jazyk:	angličtina
Zdroj:	Immunity [Immunity] 2015 Mar 17; Vol. 42 (3), pp. 524-37. Date of Electronic Publication: 2015 Mar 10.
DOI:	10.1016/j.immuni.2015.02.009
Abstrakt:	CD8(+) T cells play a critical role in limiting peripheral virus replication, yet how they locate virus-infected cells within tissues is unknown. Here, we have examined the environmental signals that CD8(+) T cells use to localize and eliminate virus-infected skin cells. Epicutaneous vaccinia virus (VV) infection, mimicking human smallpox vaccination, greatly increased expression of the CXCR3 chemokine receptor ligands CXCL9 and CXCL10 in VV-infected skin. Despite normal T cell numbers in the skin, Cxcr3(-/-) mice exhibited dramatically impaired CD8(+)-T-cell-dependent virus clearance. Intravital microscopy revealed that Cxcr3(-/-) T cells were markedly deficient in locating, engaging, and killing virus-infected cells. Further, transfer of wild-type CD8(+) T cells restored viral clearance in Cxcr3(-/-) animals. These findings demonstrate a function for CXCR3 in enhancing the ability of tissue-localized CD8(+) T cells to locate virus-infected cells and thereby exert anti-viral effector functions. (Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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