Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.

Autor:	Frankwich KA; Division of Endocrinology, University of California, San Diego., Egnatios J; School of Medicine, University of California, San Diego., Kenyon ML; VA San Diego Health System, La Jolla, CA., Rutledge TR; VA San Diego Health System, La Jolla, CA.; Department of Psychiatry, University of California, San Diego., Liao PS; Division of Endocrinology, University of California, San Diego., Gupta S; VA San Diego Health System, La Jolla, CA.; Division of Gastroenterology, University of California, San Diego., Herbst KL; Division of Endocrinology, University of California, San Diego.; VA San Diego Health System, La Jolla, CA., Zarrinpar A; VA San Diego Health System, La Jolla, CA.; Division of Gastroenterology, University of California, San Diego.
Jazyk:	angličtina
Zdroj:	Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2015 Sep; Vol. 13 (9), pp. 1625-1632.e1. Date of Electronic Publication: 2015 Mar 10.
DOI:	10.1016/j.cgh.2015.02.044
Abstrakt:	Background & Aims: Many companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss that are based on the results. We performed a randomized controlled trial to determine whether more participants who followed a nutrigenetic-guided diet lost ≥5% of their body weight than participants on a standard balanced diet for 8 and 24 weeks. Methods: We performed a prospective study of 51 obese or overweight U.S. veterans on an established weight management program at the Veterans Administration San Diego Healthcare System (the MOVE! program). Participants were randomly assigned to groups placed on a nutrigenetic-guided diet (balanced, low-carbohydrate, low-fat, or Mediterranean; n = 30) or a standard balanced diet (n = 21). Nutrigenetic diets were selected on the basis of results from the Pathway FIT test. Results: There was no significant difference in the percentage of participants on the balanced diet vs the nutrigenetic-guided diet who lost 5% of their body weight at 8 weeks (35.0% ± 20.9% vs 26.9% ± 17.1%, respectively; P = .28) or at 24 weeks. Both groups had difficulty adhering to the diets. However, adherence to the nutrigenetic-guided diet correlated with weight loss (r = 0.74; P = 4.0 × 10(-5)), but not adherence to standard therapy (r = 0.34; P = .23). Participants who had low-risk polymorphisms for obesity lost more weight than all other participants at 8 weeks (5.0% vs 2.9%, respectively; P = .02) and had significantly greater reductions in body mass index (6.4% vs 3.6%, respectively; P = .03) and waist circumference (6.5% vs 2.6%, respectively; P = .02) at 24 weeks. Conclusions: In a prospective study, a nutrigenetic-based diet did not increase weight loss compared with a standard balanced diet. However, genetic features can identify individuals most likely to benefit from a balanced diet weight loss strategy; these findings require further investigation. ClinicalTrials.gov number: NCT01859403. (Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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