Autor: |
Maranduba CM; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., De Castro SB; Department of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, Brazil., de Souza GT; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Rossato C; Department of Immunology, University of São Paulo, São Paulo, Brazil., da Guia FC; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Valente MA; Department of Nutrition, Federal University of Juiz de Fora, Governador Valadares, Brazil., Rettore JV; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Maranduba CP; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., de Souza CM; Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., do Carmo AM; Department of Clinical Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Macedo GC; Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Silva Fde S; Department of Dentistry, Federal University of Juiz de Fora, Governador Valadares, Brazil. |
Abstrakt: |
Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work-gut microbiota, immune system, and their influence in the neuroimmune system. |