Expression of TNF-α, APRIL and BCMA in Behcet's disease.

Autor: Shaker OG; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt., Tawfic SO; Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt., El-Tawdy AM; Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt., El-Komy MH; Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt., El Menyawi M; Department of Internal Medicine, Kasr Al-Aini Hospital, Faculty of Medicine, Cairo University, Giza, Egypt., Heikal AA; Department of Internal Medicine, Kasr Al-Aini Hospital, Faculty of Medicine, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2014; Vol. 2014, pp. 380405. Date of Electronic Publication: 2014 Nov 05.
DOI: 10.1155/2014/380405
Abstrakt: Background: Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.
Objective: Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.
Patients and Methods: This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.
Results: The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner (P < 0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet's disease current activity forum) index (r 0.68, P < 0.001). None of the TNF family members tested was affected by a positive pathergy test.
Conclusions: Patients have significantly higher levels of TNF family members' (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.
Databáze: MEDLINE
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