[Experience with clinical administration of new drug Thrombovasim® in vascular surgery].

Autor:	Madonov PG; Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine Novosibirsk State Medical University of the RF Public Health Ministry, Novosibirsk, Russia., Kinsht DN; Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine Novosibirsk State Medical University of the RF Public Health Ministry, Novosibirsk, Russia., Ershov KI; Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine Novosibirsk State Medical University of the RF Public Health Ministry, Novosibirsk, Russia., Shilova MA; Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine Novosibirsk State Medical University of the RF Public Health Ministry, Novosibirsk, Russia., Solov'ev ON; Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine Novosibirsk State Medical University of the RF Public Health Ministry, Novosibirsk, Russia.
Jazyk:	ruština
Zdroj:	Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery [Angiol Sosud Khir] 2015; Vol. 21 (1), pp. 99-104.
Abstrakt:	Recent years have witnessed an increased worldwide interest in medical use of unique naturally occurring enzymes - subtilisins possessing pronounced fibrinolytic and anti-inflammatory properties. The article deals with experience in clinical administration in vascular surgery of new therapeutic agent Thrombovasim® containing pegylated subtilisin as an active substance. Thrombovasim® has a favourable profile of safety, good tolerance and causes no severe haemorrhagic complications. The pharmacological action of Thrombovasim® consists in combination of the targeted effect on the fibrin carcass of the thrombus without participation of the own system of haemostasis and anti-inflammatory effect. In the Russian Federation Thrombovasim® has been used for 6 years predominantly in vascular pathology of lower limbs accompanied by the development of chronic venous insufficiency.
Databáze:	MEDLINE
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