Recurrent papillary thyroid carcinoma with pleural metastasis diagnosed by effusion cytology: a report of cases with clinicopathologic correlation.

Autor:	Sakamoto RI; Department of Pathology, The Queen's Medical Center, Honolulu, HI (RIS, CAKL, PST-N)., Sumida LC; Department of Pathology, The Queen's Medical Center, Honolulu, HI (RIS, CAKL, PST-N)., Lum CA; Department of Pathology, The Queen's Medical Center, Honolulu, HI (RIS, CAKL, PST-N)., Tauchi-Nishi PS; Department of Pathology, The Queen's Medical Center, Honolulu, HI (RIS, CAKL, PST-N).
Jazyk:	angličtina
Zdroj:	Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health [Hawaii J Med Public Health] 2015 Feb; Vol. 74 (2), pp. 51-6.
Abstrakt:	Papillary thyroid carcinoma (PTC) is typically an indolent disease characterized by slow growth and a favorable prognosis. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion. We report 3 female patients of Japanese/Okinawan ancestry with a history of PTC who presented with hydrothorax. Cytologic examination in conjunction with immunohistochemical staining enabled a definitive diagnosis of metastatic PTC. Molecular analysis of the mitogen activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways demonstrated the presence of the v-raf murine sarcoma viral oncogene homolog B (BRAF)(V600E) mutation in 2 of our 3 patients, with the absence of any other clinically significant mutations in all cases. Further investigation is necessary to elucidate the molecular and environmental mechanisms involved in this aggressive manifestation of PTC.
Databáze:	MEDLINE
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