Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models.

Autor: Tsang AC; Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Lai SS; Departments of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong., Chung WC; Departments of Mechanical Engineering, University of Hong Kong, Hong Kong., Tang AY; Departments of Mechanical Engineering, University of Hong Kong, Hong Kong., Leung GK; Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Poon AK; Departments of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong., Yu AC; Departments of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong., Chow KW; Departments of Mechanical Engineering, University of Hong Kong, Hong Kong.
Jazyk: angličtina
Zdroj: Ultrasonography (Seoul, Korea) [Ultrasonography] 2015 Apr; Vol. 34 (2), pp. 98-108. Date of Electronic Publication: 2015 Jan 31.
DOI: 10.14366/usg.14063
Abstrakt: Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial bifurcation and side-wall aneurysms.
Methods: Computational and physical models of patient-specific bifurcation and sidewall aneurysms were constructed from computed tomography angiography with use of stereolithography, a three-dimensional printing technology. Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.
Results: CFD simulations showed drastic flow reduction after flow-diverter treatment in both aneurysms. The mean volume flow rate decreased by 90% and 85% for the bifurcation aneurysm and the side-wall aneurysm, respectively. Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.
Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall aneurysms. The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.
Databáze: MEDLINE
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