Live birth and cumulative live birth rates in expected poor ovarian responders defined by the Bologna criteria following IVF/ICSI treatment.

Autor: Chai J; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China., Lee VC; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China., Yeung TW; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China., Li HW, Ho PC; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China., Ng EH; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2015 Mar 06; Vol. 10 (3), pp. e0119149. Date of Electronic Publication: 2015 Mar 06 (Print Publication: 2015).
DOI: 10.1371/journal.pone.0119149
Abstrakt: Objective: To determine the live birth and cumulative live birth rates of expected poor ovarian responders according to the Bologna criteria and to compare their outcomes with those of expected normal responders.
Design: Retrospective analysis.
Setting: University infertility clinic.
Patients: A total of 1,152 subfertile women undergoing their first in vitro fertilization (IVF) cycle.
Interventions: Women were classified into 4 groups according to the Bologna criteria for comparison.
Main Outcome Measure(s): Live birth and cumulative live birth rates.
Results: Women with expected poor response (POR) had the lowest live birth rate than the other 3 groups (23.8%, p = 0.031). Cumulative live birth rates were significantly lower in those with expected POR than those with expected normal ovarian response (NOR) (35.8% vs 62.8%, p<0.0001). In the subgroup analysis, the cumulative live birth rates in expected PORs were significantly lower in those who had ≤3 oocytes retrieved (18.6% for ≤3 oocytes vs 44.0% for >3 oocytes, p = 0.006) whereas the live birth rates in fresh cycle did not differ (17.8% vs 30.9%, p = 0.108).
Conclusion: Women who were expected POR according to the Bologna criteria had lower live birth and cumulative live birth than expected NOR but they still can achieve reasonable treatment outcomes and IVF treatment should not be precluded.
Databáze: MEDLINE
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