| Autor: |
Haakenson J; University of South Florida, Tampa, FL., Wu JY; University of South Florida, Tampa, FL., Xiang S; University of South Florida, Tampa, FL., Williams KA; University of South Florida, Tampa, FL., Bai W; University of South Florida, Tampa, FL; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Zhang X; University of South Florida, Tampa, FL; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. |
| Abstrakt: |
Histone deacetylase 6 (HDAC6) is emerging as a novel therapeutic target in cancer treatment. HDAC6 plays an important role in cell migration, cell transformation, and DNA damage response. Our and others' studies have linked HDAC6's functions and HDAC6's regulation to the mitogen-activated protein kinase (MAPK) pathways. In particular, HDAC6's activity has been found to be regulated by EGF-EGFR-Ras-Raf-MEK-ERK signaling. Inversely, HDAC6 has been reported to modulate the functions of EGFR and Ras. In this review, we summarize the literature on HDAC6 and MAPK pathways, and emphasize the interaction between HDAC6 and the ERK-MAPK signaling cascade. |
