HLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais.

Autor:	Vejbaesya S; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Thongpradit R; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Kalayanarooj S; Queen Sirikit National Institute of Child Health., Luangtrakool K; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Luangtrakool P; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Gibbons RV; Department of Virology, Armed Forces Research Institute of Medical Science, Bangkok, Thailand., Srinak D; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Ngammthaworn S; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Apisawes K; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Yoon IK; Department of Virology, Armed Forces Research Institute of Medical Science, Bangkok, Thailand., Thomas SJ; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland., Jarman RG; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland., Srikiakthachorn A; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester., Green S; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester., Chandanayingyong D; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University., Park S; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University., Friedman J; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University., Rothman AL; Institute for Immunology and Informatics, University of Rhode Island, Providence., Stephens HA; Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University UCL Centre for Nephrology and Anthony Nolan Laboratories, Royal Free NHS Foundation Trust, Royal Free Hospital, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2015 Sep 15; Vol. 212 (6), pp. 939-47. Date of Electronic Publication: 2015 Mar 04.
DOI:	10.1093/infdis/jiv127
Abstrakt:	Background: Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system. Objectives: To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness. Methods: Seven hundred sixty-two patients and population-matched controls recruited predominantly in Bangkok were HLA-A and -B typed. HLA supertype frequencies were compared and tested for significant dengue disease associations using logistic regression analyses. Multivariable models were built by conducting forward stepwise selection procedures. Results: In the final logistic regression model, the HLA-B44 supertype was protective against dengue hemorrhagic fever (DHF) in secondary infections (odds ratio [OR] = 0.46, 95% confidence interval [CI], .30-.72), while the HLA-A02 supertype (OR = 1.92, 95% CI, 1.30-2.83) and the HLA-A01/03 supertype (OR = 3.01, 95% CI, 1.01-8.92) were associated with susceptibility to secondary dengue fever. The B07 supertype was associated with susceptibility to secondary DHF in the univariate analysis (OR = 1.60, 95% CI, 1.05-2.46), whereas that was not retained in the final model. Conclusions: As the HLA-B44 supertype is predicted to target conserved epitopes in dengue, our results suggest that B44 supertype-restricted immune responses to highly conserved regions of the dengue proteome may protect against secondary DHF. (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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