The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.

Autor: Sarapultsev PA; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia., Chupakhin ON; The IJ Postovsky Institute of Organic Synthesis of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia., Medvedeva SU; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia., Mukhlynina EA; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia., Brilliant SA; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia., Sidorova LP; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia., Danilova IG; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia., Sarapultsev AP; Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia. Electronic address: a.sarapultsev@gmail.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2015 Apr; Vol. 25 (2), pp. 440-9. Date of Electronic Publication: 2015 Mar 01.
DOI: 10.1016/j.intimp.2015.02.024
Abstrakt: A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6h a day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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