Reproductive safety evaluation of L-Ergothioneine.

Autor: Forster R; CiToxLAB, Evreux 27005, France. Electronic address: roy.forster@fr.citoxlab.com., Spézia F; CiToxLAB, Evreux 27005, France., Papineau D; CiToxLAB, Evreux 27005, France., Sabadie C; CiToxLAB, Evreux 27005, France., Erdelmeier I; Tetrahedron, Vincennes 94300, France., Moutet M; Tetrahedron, Vincennes 94300, France., Yadan JC; Tetrahedron, Vincennes 94300, France.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2015 Jun; Vol. 80, pp. 85-91. Date of Electronic Publication: 2015 Feb 28.
DOI: 10.1016/j.fct.2015.02.019
Abstrakt: L-Ergothioneine is a naturally occurring histidine-derived betaine (CAS No: 497-30-3) synthesized by bacteria and fungi, and found ubiquitously in plants and animals. It is present in many human foodstuffs. We evaluated the potential reproductive toxicity of L-Ergothioneine in Sprague-Dawley rats. L-Ergothioneine was administered at concentrations of 0.1, 0.3 or 0.9% in diet to F0 males (for 10 weeks before pairing and 3 weeks during pairing) and F0 females (for 13 weeks before pairing, during pairing and gestation, and until day 5 of lactation). Systemic exposure increased with dose-level, but not dose proportionally, suggesting saturation of uptake mechanisms. No clinical signs of toxicity were observed and there were no effects of L-Ergothioneine treatment on mating and reproductive performance or parameters of fertility. All animals mated within a similar number of days and pregnancy rates were uniformly high in control and treated groups. There were no effects of treatment with L-Ergothioneine on the duration of gestation, pre- and post-implantation losses, number of pups delivered and viability index, or on litter parameters (litter size, clinical signs, body weight or sex ratio) and the repartition of found dead/cannibalized pups. In conclusion, L-Ergothioneine was well tolerated and without adverse effects on the reproductive parameters evaluated.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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