Cell adhesion in epidermal development and barrier formation.

Autor:	Sumigray KD; Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA., Lechler T; Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: terry.lechler@duke.edu.
Jazyk:	angličtina
Zdroj:	Current topics in developmental biology [Curr Top Dev Biol] 2015; Vol. 112, pp. 383-414. Date of Electronic Publication: 2015 Feb 11.
DOI:	10.1016/bs.ctdb.2014.11.027
Abstrakt:	Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of individual cell-cell junctions and their composite proteins in regulating epidermal development and function. In addition to individual adhesive functions, we will discuss emerging ideas on mechanosensation/transduction of junctions in the epidermis, noncanonical roles for adhesion proteins, and crosstalk/interdependencies between the junctional systems. These studies have revealed that cell adhesion proteins are connected to many aspects of tissue physiology including growth control, differentiation, and inflammation. (© 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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