Normal values of 24-hour ambulatory esophageal impedance-pH monitoring in a rural South African cohort of healthy participants.

Autor: Ndebia EJ; Department of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa., Sammon AM; Department of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa., Umapathy E; Department of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa., Iputo JE; Department of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
Jazyk: angličtina
Zdroj: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2016 May; Vol. 29 (4), pp. 385-91. Date of Electronic Publication: 2015 Feb 27.
DOI: 10.1111/dote.12333
Abstrakt: There are no data on 24-hour multichannel intraluminal impedance and pH monitoring in African populations. The purpose of this study was to provide the normal values of esophageal impedance and pH monitoring in a rural African populations. South African healthy rural participants were recruited and underwent 24 hours of esophageal impedance and pH monitoring. The median and the 95th percentiles of the total reflux episodes were 49 and 97, respectively, of which the corresponding number of acidic, weakly acidic, and weakly alkaline reflux were 15 and 55, 17 and 51, and 8 and 36, respectively. The compositions of the total reflux were 5 and 21 for liquid, 27 and 72 for mixed, and 10 and 39 for gas reflux, respectively. The median bolus clearance was 18 seconds and the median bolus exposure was 14 minutes/24 hours. The proximal extent was 6%. The 95th percent time of esophageal exposure to acid was 8.6 in 24 hours. Female and overweight participants were associated with an increased number of reflux events. There were more reflux episodes, and of which, more were weakly alkaline compared with previous similar studies. The findings provide reference values of gastroesophageal reflux for a South African rural population.
(© 2015 International Society for Diseases of the Esophagus.)
Databáze: MEDLINE