| Autor: |
Poleshko AG, Lobanok ES, Mezhevikina LM, Fesenko EE, Volotkovskiĭ ID |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2014 Nov-Dec; Vol. 59 (6), pp. 1125-30. |
| Abstrakt: |
It was demonstrated that fibroblast growth factor bFGF influences the process of heme synthesis, the proliferation activity and viability of bone marrow mesenchymal stem cells in culture under hypoxic conditions. The addition of fibroblast growth factor bFGF (7 ng/ml) to the medium under above conditions led to the accumulation of aminolevulinic acid--an early porphyrin and heme precursor, an increase in CD 71 expression--a transferrin receptor, and also a decrease in porphyrin pigments and heme contents--a late precursor and end products of heme synthesis, respectively. It was found that cultivation of the cells under hypoxic conditions and bFGF is an optimum to maintain high viability and proliferation capacity of the mesenchymal stem cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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