[Oxidative stress in uveitis and its correction with superoxide dismutase antioxidative enzyme (experimental study)].

Autor:	Chesnokova NB, Neroev VV, Beznos OV, Beĭshenova GA, Nikol'skaia II, Kost OA, Binevskiĭ PV, Shekhter AB
Jazyk:	ruština
Zdroj:	Vestnik oftalmologii [Vestn Oftalmol] 2014 Sep-Oct; Vol. 130 (5), pp. 30-4.
Abstrakt:	Objective: to study the influence of experimental uveitis on those biochemical parameters of aqueous humor that reflect inflammation acuity as well as local antioxidant and local antiproteolytic activity; to study the effect of topical superoxide dismutase (SOD) on the clinical course of uveitis and ocular metabolism. Material and Methods: Acute uveitis was induced in rabbits by a double injection (subcutaneous and intravitreal) of normal horse serum. The following parameters of aqueous humor were measured: protein concentration, antioxidant activity, SOD activity, alpha2-macroglobulin level, total nitrates and nitrites, and leukocyte number. Clinical assessment and histopathological study were performed. Results: It was found that uveitis is associated with a statistically significant increase in protein concentration, leukocyte number, SOD activity, and alpha2-macroglobulin level in aqueous humor as well as a decrease in anti-hydroxyl radical activity. SOD instillations contributed to the reduction of the listed parameters and improvement of the antioxidant activity. Clinical presentations of uveitis also became less pronounced. Conclusion: SOD instillations for oxidative stress correction help reduce clinical presentations of uveitis, which is confirmed by biochemical examination.
Databáze:	MEDLINE
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