| Autor: |
Lebovka IIu, Kozhina TN, Fedorova IV, Peshekhonov VT, Evstiukhina TA, Chernenkov AIu, Korolev VG |
| Jazyk: |
ruština |
| Zdroj: |
Genetika [Genetika] 2014 Jan; Vol. 50 (1), pp. 5-11. |
| Abstrakt: |
SIN3 gene product operates as a repressor for a huge amount of genes in Saccharomyces cerevisiae. Sin3 protein with a mass of about 175 kDa is a member of the RPD3 protein complex with an assessed mass of greater than 2 million Da. It was previously shownthat RPD3 gene mutations influence recombination and repair processes in S. cerevisiae yeasts. We studied the impacts of the sin3 mutation on UV-light sensitivity and UV-induced mutagenesis in budding yeast cells. The deletion ofthe SIN3 gene causes weak UV-sensitivity of mutant budding cells as compared to the wild-type strain. These results show that the sin3 mutation decreases both spontaneous and UV-induced levels of levels. This fact is hypothetically related to themalfunction of ribonucleotide reductase activity regulation, which leads to a decrease in the dNTP pool and the inaccurate error-prone damage bypass postreplication repair pathway, which in turn provokes a reduction in the incidence of mutations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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