A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women.

Autor:	Tartibian B; Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University, Urmia, Iran., FitzGerald LZ; UCLA School of Nursing, Los Angeles, CA, USA lfitzger@sonnet.ucla.edu., Azadpour N; Faculty of Sport Sciences, Hacettepe University, Ankara, Turkey., Maleki BH; Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University, Urmia, Iran.
Jazyk:	angličtina
Zdroj:	Post reproductive health [Post Reprod Health] 2015 Mar; Vol. 21 (1), pp. 9-15. Date of Electronic Publication: 2015 Feb 20.
DOI:	10.1177/2053369114565708
Abstrakt:	Background: Elevated plasma levels of inflammatory cytokine are associated with body mass index, percent body fat and increased morbidity. Evidence suggests that higher levels of physical activity result in beneficial anti-inflammatory effects compared to a more sedentary lifestyle. Further, reproductive hormones are associated with inflammaotry cytokines. This study examined the effect of a 16-week low-moderate intensity exercise (EX) programme on reproductive hormones and inflammatory cytokines. Methods: Twenty-eight healthy, sedentary post-menopausal women were randomly assigned to EX (n = 14) or control (Con, n = 14) groups. The EX group completed low-moderate intensity treadmill training 25-30 min/day, up to 55% of HRmax, 3-4 days/week, for 16-weeks. Con maintained current physical activity level. Baseline and week-16 serum samples evaluated interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, C-reactive protein, estradiol, luteinizing hormone and follicular stimulating hormone. Results: Post-intervention, the EX group showed a significant decrease in interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, estradiol, follicular stimulating hormone and luteinizing hormone levels compared to baseline values. No significant changes were observed in Con. Significant correlations were observed between IL-1β, IL-6, TNF-α, and reproductive hormones, both before and after the exercise intervention. Conclusion: Findings suggest that a low-moderate intensity EX programme decreases cytokines in relation to reproductive hormones in post-menopausal women. These findings support the role of EX in reducing inflammatory markers and improved reproductive hormones in post-menopausal women. (© The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.)
Databáze:	MEDLINE
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