| Autor: |
Carvalho KM; Post-Graduate Programme in Medical Sciences, Faculty of Medicine, Federal University of Ceará, 60430-140 Fortaleza, CE, Brazil ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., Marinho Filho JD; Post-Graduate Programme in Medical Sciences, Faculty of Medicine, Federal University of Ceará, 60430-140 Fortaleza, CE, Brazil ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., de Melo TS; Faculty of Pharmacy, Odontology and Nurse, Federal University of Ceará, 60430-160 Fortaleza, CE, Brazil., Araújo AJ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., Quetz Jda S; INCT-IBISAB-Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., da Cunha Mdo P; Haroldo Juaçaba Hospital, Cancer Institute of Ceará, 60430-230 Fortaleza, CE, Brazil., de Melo KM; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., da Silva AA; Department of Organic Chemistry, Federal University of Piauí, 64049-550 Teresina, PI, Brazil., Tomé AR; Faculty of Veterinary Medicine, State University of Ceará, 60740-000 Fortaleza, CE, Brazil., Havt A; INCT-IBISAB-Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., Fonseca SG; Faculty of Pharmacy, Odontology and Nurse, Federal University of Ceará, 60430-160 Fortaleza, CE, Brazil., Brito GA; Department of Morphology, Faculty of Medicine, Federal University of Ceará, 60430-170 Fortaleza, CE, Brazil., Chaves MH; Department of Organic Chemistry, Federal University of Piauí, 64049-550 Teresina, PI, Brazil., Rao VS; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil ; INCT-IBISAB-Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil., Santos FA; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil ; INCT-IBISAB-Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil. |
| Abstrakt: |
Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin from Protium heptaphyllum (RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation. |
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