| Autor: |
Rodgers ZL; Department of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and § Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States., Hughes RM, Doherty LM, Shell JR, Molesky BP, Brugh AM, Forbes MD, Moran AM, Lawrence DS |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2015 Mar 11; Vol. 137 (9), pp. 3372-8. Date of Electronic Publication: 2015 Feb 27. |
| DOI: |
10.1021/jacs.5b00182 |
| Abstrakt: |
Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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