C-peptide as a risk factor of coronary artery disease in the general population.

Autor:	Cabrera de León A; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain University of La Laguna, La Laguna, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain acableo@gobiernodecanarias.org., Oliva García JG; Endocrine Diseases Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain., Marcelino Rodríguez I; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain., Almeida González D; Cardiovascular Research Network of the Carlos III Institute of Health, Spain Immunology Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain., Alemán Sánchez JJ; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain., Brito Díaz B; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain., Domínguez Coello S; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain., Bertomeu Martínez V; Cardiovascular Research Network of the Carlos III Institute of Health, Spain Servicio de Cardiología, Hospital San Juan, Universidad Miguel Hernández, Alicante, Spain., Aguirre Jaime A; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain., Rodríguez Pérez Mdel C; Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain.
Jazyk:	angličtina
Zdroj:	Diabetes & vascular disease research [Diab Vasc Dis Res] 2015 May; Vol. 12 (3), pp. 199-207. Date of Electronic Publication: 2015 Feb 12.
DOI:	10.1177/1479164114564900
Abstrakt:	Objective: To analyse the association between serum C-peptide and coronary artery disease in the general population. Methods: Follow-up study of 6630 adults from the general population. They were stratified into group 1 (no insulin resistance: C-peptide < third tercile and glycaemia < 100 mg/dL), group 2 (initial insulin resistance: C-peptide ⩾ third tercile and glycaemia < 100 mg/dL) and group 3 (advanced insulin resistance: glycaemia ⩾ 100 mg/dL). Results: After 3.5 years of follow-up, group 2 had a higher incidence of myocardial infarction (relative risk (RR) = 4.2, 95% confidence interval (CI) = 1.7-10.6) and coronary artery disease (RR = 3.5, 95% CI = 1.9-6.6) than group 1. Group 3 also had increased incidences of both diseases. In multivariable analysis of the entire population, groups 2 and 3 showed significant risks of myocardial infarction and coronary artery disease (RR > 3 and RR > 2, respectively). However, when people with diabetes were excluded, the increased risks were corroborated only in group 2 for myocardial infarction (RR = 2.8, 95% CI = 1.1-6.9; p = 0.025) and coronary artery disease (RR = 2.4, 95% CI = 1.3-4.6; p = 0.007). Conclusion: Elevated C-peptide is associated with the incidence of myocardial infarction and coronary artery disease in the general population. It can be an earlier predictor of coronary events than impaired fasting glucose. (© The Author(s) 2015.)
Databáze:	MEDLINE
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