| Autor: |
Barcelos GR; Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/no, Ribeirão Preto, São Paulo, CEP 14040-903, Brazil, barcelos@fcfrp.usp.br., De Marco KC, de Rezende VB, Braga GÚ, Antunes LM, Tanus-Santos JE, Barbosa F Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of environmental contamination and toxicology [Arch Environ Contam Toxicol] 2015 Aug; Vol. 69 (2), pp. 173-80. Date of Electronic Publication: 2015 Feb 18. |
| DOI: |
10.1007/s00244-015-0137-8 |
| Abstrakt: |
The aim of the present study was to evaluate possible effects of endothelial nitric oxide synthase (eNOS) polymorphisms on systolic (SBP) and diastolic blood pressure (DBP) and on nitrite levels in plasma (NitP) in a population coexposed to methylhemoglobin (MeHg) and lead (Pb) in the Amazonian region, Brazil. Plasmatic levels of hemoglobin Hg (HgP) and Pb (PbP) were determined by inductively coupled plasma-mass spectrometry, whereas NitP were quantified by chemiluminescence. Genotyping was performed by conventional and restriction fragment length polymorphism-polymerase chain reaction assay. The population age ranged from 18 to 87 years (mean 40 ± 16), and the distribution between the sexes was homogenous (63 men and 50 women). Mean HgP and PbP were 7.1 ± 6.1 and 1.1 ± 1.1 µg L(-1), respectively. PbP was correlated to SBP and DBP, whereas no effects were observed for HgP on blood pressure. Subjects carrying the 4b allele in intron 4 presented greater SBP and DBP compared with those who had the 4a4a genotype. In addition, interactions between alcohol consumption and the -786 T/C polymorphism were observed on NitP, i.e., individuals carrying the polymorphic allele and drinkers had lower NitP. Taken together, our data give new insights concerning the genetic effects of eNOS polymorphisms on biomarkers related to cardiovascular status in populations coexposed to Hg and Pb. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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