Optimization of Aqueous SI-ATRP Grafting of Poly(Oligo(Ethylene Glycol) Methacrylate) Brushes from Benzyl Chloride Macroinitiator Surfaces.

Autor: Rodda AE; Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia. andrew.rodda@monash.edu.; CSIRO Materials Science and Engineering, Bayview Avenue, Clayton 3168, Victoria, Australia, and Cooperative Research Centre for Polymers, 8 Redwood Drive, Notting Hill, 3168, Victoria, Australia. andrew.rodda@monash.edu., Ercole F; Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia., Nisbet DR; School of Engineering, The Australian National University, Canberra, 0200, Australian Capital Territory, Australia., Forsythe JS; Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia., Meagher L; CSIRO Materials Science and Engineering, Bayview Avenue, Clayton 3168, Victoria, Australia, and Cooperative Research Centre for Polymers, 8 Redwood Drive, Notting Hill, 3168, Victoria, Australia.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2015 Jun; Vol. 15 (6), pp. 799-811. Date of Electronic Publication: 2015 Feb 17.
DOI: 10.1002/mabi.201400512
Abstrakt: Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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