Prevalence of Duchenne and Becker muscular dystrophies in the United States.

Autor: Romitti PA; The University of Iowa, Iowa City, Iowa; paul-romitti@uiowa.edu., Zhu Y; The University of Iowa, Iowa City, Iowa;, Puzhankara S; The University of Iowa, Iowa City, Iowa;, James KA; University of Colorado, Aurora, Colorado;, Nabukera SK; The University of Iowa, Iowa City, Iowa;, Zamba GK; The University of Iowa, Iowa City, Iowa;, Ciafaloni E; University of Rochester, Rochester, New York;, Cunniff C; The University of Arizona, Tucson, Arizona;, Druschel CM; New York State Department of Health, Albany, New York; State University of New York, Albany, Rensselaer, New York; and., Mathews KD; The University of Iowa, Iowa City, Iowa;, Matthews DJ; University of Colorado, Aurora, Colorado;, Meaney FJ; The University of Arizona, Tucson, Arizona;, Andrews JG; The University of Arizona, Tucson, Arizona;, Conway KM; The University of Iowa, Iowa City, Iowa;, Fox DJ; New York State Department of Health, Albany, New York;, Street N; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia., Adams MM; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia., Bolen J; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jazyk: angličtina
Zdroj: Pediatrics [Pediatrics] 2015 Mar; Vol. 135 (3), pp. 513-21. Date of Electronic Publication: 2015 Feb 16.
DOI: 10.1542/peds.2014-2044
Abstrakt: Objective: To estimate prevalence of childhood-onset Duchenne and Becker muscular dystrophies (DBMD) in 6 sites in the United States by race/ethnicity and phenotype (Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]).
Methods: In 2002, the Centers for Disease Control and Prevention established the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) to conduct longitudinal, population-based surveillance and research of DBMD in the United States. Six sites conducted active, multiple-source case finding and record abstraction to identify MD STARnet cases born January 1982 to December 2011. We used cross-sectional analyses to estimate prevalence of DBMD per 10 000 boys, ages 5 to 9 years, for 4 quinquennia (1991-1995, 1996-2000, 2001-2005, and 2006-2010) and prevalence per 10 000 male individuals, ages 5 to 24 years, in 2010. Prevalence was also estimated by race/ethnicity and phenotype.
Results: Overall, 649 cases resided in an MD STARnet site during ≥1 quinquennia. Prevalence estimates per 10 000 boys, ages 5 to 9 years, were 1.93, 2.05, 2.04, and 1.51, respectively, for 1991-1995, 1996-2000, 2001-2005, and 2006-2010. Prevalence tended to be higher for Hispanic individuals than non-Hispanic white or black individuals, and higher for DMD than BMD. In 2010, prevalence of DBMD was 1.38 per 10 000 male individuals, ages 5 to 24 years.
Conclusions: We present population-based prevalence estimates for DBMD in 6 US sites. Prevalence differed by race/ethnicity, suggesting potential cultural and socioeconomic influences in the diagnosis of DBMD. Prevalence also was higher for DMD than BMD. Continued longitudinal surveillance will permit us to examine racial/ethnic and socioeconomic differences in treatment and outcomes for MD STARnet cases.
(Copyright © 2015 by the American Academy of Pediatrics.)
Databáze: MEDLINE