Prognostic factors and survival in patients with gastric stump cancer.

Autor:	Huang H; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Wang W; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Chen Z; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Jin JJ; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Long ZW; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Cai H; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Liu XW; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Zhou Y; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Wang YN; Hua Huang, Jie-Jie Jin, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2015 Feb 14; Vol. 21 (6), pp. 1865-71.
DOI:	10.3748/wjg.v21.i6.1865
Abstrakt:	Aim: To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer (GSC). Methods: The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center. The prognostic factors were analyzed with Cox proportional hazard models. Results: GSC tended to occur within 25 years following the primary surgery, when the initial disease is benign, whereas it primarily occurred within the first 15 years post-operation for gastric cancer. Patients with regular follow-up after primary surgery had a better survival rate. The multivariate Cox regression analysis revealed that Borrmann type I/II (HR = 3.165, 95%CI: 1.055-9.500, P = 0.040) and radical resection (HR = 1.780, 95%CI: 1.061-2.987, P = 0.029) were independent prognostic factors for GSC. The overall 1-, 3-, and 5-year survival rates of the 92 patients were 78.3%, 45.6% and 27.6%, respectively. The 1-, 3-, and 5-year survival rates of those undergoing radical resection were 79.3%, 52.2%, and 37.8%, respectively. The 5-year survival rates for stages I, II, III, and IV were 85.7%, 47.4%, 16.0%, and 13.3%, respectively (P = 0.005). Conclusion: The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease. Therefore, close follow-up is necessary. The overall survival of patients with GSC is poor, and curative resection can improve their prognosis.
Databáze:	MEDLINE
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