The Association of Serum Galectin-3 Levels with Atrial Electrical and Structural Remodeling.

Autor: Yalcin MU; Department of Cardiology, Hakkari State Hospital, Hakkari, Turkey., Gurses KM; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Kocyigit D; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Canpinar H; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey., Canpolat U; Department of Cardiology, Turkiye Yuksek Ihtisas Research and Traning Hospital, Ankara, Turkey., Evranos B; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Yorgun H; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Sahiner ML; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Kaya EB; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Hazirolan T; Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Tokgozoglu L; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Oto MA; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Ozer N; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Guc D; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey., Aytemir K; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2015 Jun; Vol. 26 (6), pp. 635-40. Date of Electronic Publication: 2015 Mar 27.
DOI: 10.1111/jce.12637
Abstrakt: Introduction: Left atrial (LA) interstitial fibrosis is known to have a role in the initiation and maintenance of atrial fibrillation (AF). The role of galectin-3 in the pathogenesis of cardiac fibrosis has been demonstrated in previous studies. We aimed to determine whether serum galectin-3 level is associated with markers of atrial remodeling, including the extent of LA fibrosis detected by delayed enhancement magnetic resonance imaging (DE-MRI) and atrial electromechanical delay (AEMD) in paroxysmal AF patients with preserved left ventricular (LV) functions.
Methods and Results: Thirty-three patients (58 [28-74] years, 51.5% male) with paroxysmal AF who underwent DE-MRI prior to cryoballoon-based AF ablation were included in the study. Serum galectin-3 levels were measured with ELISA. LA volume index (B ± SE: 0.424 ± 0.504, 95% CI: 0.560-2.627, P = 0.004) and serum galectin-3 levels (B ± SE: 0.549 ± 7.745, 95% CI: 16.874-47.550, P < 0.001) were found to be independently correlated with extent of LA fibrosis detected with DE-MRI in paroxysmal AF patients with preserved LV function. Correlation analysis between AEMD parameters and baseline characteristics showed that galectin-3 was significantly correlated with intra-left (ρ = 0.432, P = 0.012) and inter-AEMD (ρ = 0.395, P = 0.023). Duration of AF, LAD, and extent of LA fibrosis were also found to be significantly correlated with AEMD parameters.
Conclusion: This is a hypothesis-generating study pointing out that serum galectin-3 level is significantly associated with atrial remodeling in paroxysmal AF patients with preserved LV function. Further studies are necessary to provide exact pathophysiological mechanisms.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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