Magnetic resonance sentinel lymph node imaging of the prostate with gadofosveset trisodium-albumin: preliminary results in a canine model.

Autor:	Turkbey B; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088. Electronic address: turkbeyi@mail.nih.gov., Hoyt RF Jr; Laboratory of Animal Medicine and Surgery NHLBI, NIH, Bethesda, Maryland; Laboratory Animal Science Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland., Agarwal HK; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088; Philips Research North America, Briarcliff Manor, New York., Bernardo M; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088; Laboratory Animal Science Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland., Sankineni S; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088., Johnson L; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088., Grant KB; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088., Rais-Bahrami S; Urologic Oncology Branch, NCI, NIH, Bethesda, Maryland., Kobayashi H; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088., Wood BJ; Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland., Pinto PA; Urologic Oncology Branch, NCI, NIH, Bethesda, Maryland; Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland., Griffiths GL; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland., Choyke PL; Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088.
Jazyk:	angličtina
Zdroj:	Academic radiology [Acad Radiol] 2015 May; Vol. 22 (5), pp. 646-52. Date of Electronic Publication: 2015 Feb 13.
DOI:	10.1016/j.acra.2014.12.021
Abstrakt:	Rationale and Objectives: To determine if intraprostatic injection of gadofosveset trisodium mixed with human serum albumin (HSA) can identify sentinel lymph nodes (LNs) draining the prostate on magnetic resonance imaging (MRI) in a canine model. Materials and Methods: Three male canines weighing between 25.7 and 41.3 kg were anesthetized, placed in a 3-T MRI, and a needle was placed transrectally into one side of the prostate using a commercially available intrarectal needle guide. Gadofosveset trisodium premixed with 10% HSA was then administered at doses ranging from 0.1 to 2.5 mL. T1W MRI was performed immediately after injection, and two readers evaluated images for visualization of LNs draining the prostate. Results: Intraprostatic injection of 0.2 mL gadofosveset trisodium premixed with HSA identified the draining periprostatic LNs in all cases. Delayed images demonstrated upper echelon nodes in the pelvis and the abdomen. Higher volume injections resulted in excessive periprostatic extravasation, whereas lower volume injections resulted in suboptimal visualization of LNs. Conclusions: We demonstrate that gadofosveset trisodium (premixed with 10% HSA) injected intraprostatically at 0.2 mL visualized LNs draining the prostate. This approach can be readily adapted for clinical applications such as sentinel LN imaging in prostate cancer patients before surgery. (Published by Elsevier Inc.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu