M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study.

Autor: Thean Hock T; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia. Electronic address: tangth.amdi@usm.edu.my., Bogdanova N; Institute of Human Genetics, University of Muenster, Muenster, Germany., Kai Cheen A; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia., Kathirgamanathan S; Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia., Bin Abdullah R; Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia., Mohd Yusoff N; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia., Zaidah Abdullah W; School of Medical Sciences, Universiti Sains Malaysia, Penang, Malaysia., Syima Abdul Manaf F; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia., Wieacker P; Institute of Human Genetics, University of Muenster, Muenster, Germany., Markoff A; Institute of Human Genetics, University of Muenster, Muenster, Germany. Electronic address: markoff@uni-muenster.de.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2015 Apr; Vol. 30 (4), pp. 434-9. Date of Electronic Publication: 2015 Jan 13.
DOI: 10.1016/j.rbmo.2014.12.014
Abstrakt: Recurrent spontaneous abortion (RSA) is a prevalent condition among the Malay population of Malaysia, where carriage risk of conventional hereditary thrombophilia factors has been generally ruled out. The contribution of M2/ANXA5, a common haplotype in the annexin A5 gene promoter, was evalauted for RSA in Malay. Seventy-seven women who had experienced two or more unexplained RSA and 41 available male partners were selected for study, with 360 population controls recruited from healthy Malay individuals. Incidence of M2 carriage and odds ratios were calculated between control and patient groups, and clinically defined subgroups and RSA risk was evaluated. M2/ANXA5, found in 42.2% of the general Malay population, was associated with greater risks for women with primary and secondary RSA with early (gestational week 5-15) losses. The risk was somewhat higher in Malay couples when both partners were carriers and a trend of higher prevalence was seen for the male partners patients who had experienced RSA. M2 carriage seems to be a risk factor with unusually high incidence in Malay women and couples with primary and secondary RSA with 'early' spontaneous abortions. The associated male partner risk confirms the proposed role of M2/ANXA5 as a genetic trait impeding embryonic anticoagulation.
(Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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