Predictive factors of functional capacity and real-world functioning in patients with schizophrenia.

Autor:	Menendez-Miranda I; Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain., Garcia-Portilla MP; Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain., Garcia-Alvarez L; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain. Electronic address: lettti@gmail.com., Arrojo M; Servicio de Psiquiatría, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain., Sanchez P; Unidad de Psicosis Refractarias, Hospital Psiquiátrico de Alava, Vitoria, Spain., Sarramea F; ESM Montoro, Hospital Reina Sofía de Córdoba, Spain., Gomar J; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain; Litwin Zucker Alzheimer's Disease Center, Feinstein Institute for Medical Research/AECOM, Manhassett, NY; FIDMAG, Hermanas Hospitalarias Sant Boi de Llobregat, Spain., Bobes-Bascaran MT; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain., Sierra P; Servicio de Psiquiatria, Hospital Universitario La Fe, Avda, Fernando Abril Martorell 106, 46026 Valencia, Spain., Saiz PA; Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain., Bobes J; Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
Jazyk:	angličtina
Zdroj:	European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2015 Jul; Vol. 30 (5), pp. 622-7. Date of Electronic Publication: 2015 Feb 10.
DOI:	10.1016/j.eurpsy.2014.12.011
Abstrakt:	Purpose: This study was performed to identify the predictive factors of functional capacity assessed by the Spanish University of California Performance Skills Assessment (Sp-UPSA) and real-world functioning assessed by the Spanish Personal and Social Performance scale (PSP) in outpatients with schizophrenia. Methods: Naturalistic, 6-month follow-up, multicentre, validation study. Here, we report data on 139 patients with schizophrenia at their baseline visit. Assessment: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S), Sp-UPSA and PSP. Statistics: Pearson's correlation coefficient (r) was used to determine the relationships between variables, and multivariable stepwise linear regression analyses to identify predictive variables of Sp-UPSA and PSP total scores. Results: Functional capacity: scores on the PSP and PANSS-GP entered first and second at P<0.0001 and accounted for 21% of variance (R(2)=0.208, model df=2, F=15.724, P<0.0001). Real-world functioning: scores on the CGI-S (B=-5.406), PANSS-N (B=-0.657) and Sp-UPSA (B=0.230) entered first, second and third, and accounted for 51% of variance (model df=3, F=37.741, P<0.0001). Conclusion: In patients with schizophrenia, functional capacity and real-world functioning are two related but different constructs. Each one predicts the other along with other factors; general psychopathology for functional capacity, and severity of the illness and negative symptoms for real-world functioning. These findings have important clinical implications: (1) both types of functioning should be assessed in patients with schizophrenia and (2) strategies for improving them should be different. (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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