Interleukin-10 but not transforming growth factor-β1 gene expression is up-regulated by vitamin D treatment in multiple sclerosis patients.

Autor: Farsani ZS; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Behmanesh M; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: behmanesh@modares.ac.ir., Sahraian MA; MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2015 Mar 15; Vol. 350 (1-2), pp. 18-23. Date of Electronic Publication: 2015 Jan 28.
DOI: 10.1016/j.jns.2015.01.030
Abstrakt: Multiple sclerosis (MS) is an inflammatory and autoimmune disease. Variety of different genetics and environmental factors are involved in MS pathology. The epidemiological studies demonstrated that vitamin D has immune and immunomodulating effects on MS disease. Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1) genes in MS patients. We found that, the expression level of IL-10 gene in treated patients was up-regulated 3.84 times more than before treatment, but the expression level of TGF-β1 was not affected by vitamin D treatment. Also, a significant relationship was observed between vitamin D level and EDSS in MS patients. Our results indicated that the increased level of serum vitamin D and IL-10 gene expression may be associated with the reduction of EDSS scores in MS patients.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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