Pernicious anemia. From past to present.

Autor: Rodríguez de Santiago E; Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: e_rodriguez_de_santiago@hotmail.com., Ferre Aracil C; Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España., García García de Paredes A; Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España., Moreira Vicente VF; Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España.
Jazyk: English; Spanish; Castilian
Zdroj: Revista clinica espanola [Rev Clin Esp (Barc)] 2015 Jun-Jul; Vol. 215 (5), pp. 276-84. Date of Electronic Publication: 2015 Feb 11.
DOI: 10.1016/j.rce.2014.12.013
Abstrakt: Pernicious anemia is currently the most common cause of vitamin B12 deficiency in Western countries. The histological lesion upon which this condition is based is autoimmune chronic atrophic gastritis. The destruction of parietal cells causes a deficiency in intrinsic factor, an essential protein for vitamin B12 absorption in the terminal ileum. Advances in the last two decades have reopened the debate on a disease that seemed to have been forgotten due to its apparent simplicity. The new role of H. pylori, the value of parietal cell antibodies and intrinsic factor antibodies, the true usefulness of serum vitamin B12 levels, the risk of adenocarcinoma and gastric carcinoids and oral vitamin B12 treatment are just some of the current issues analyzed in depth in this review.
(Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Medicina Interna (SEMI). All rights reserved.)
Databáze: MEDLINE
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