Endocrine aspects of organelle stress—cell non-autonomous signaling of mitochondria and the ER.

Autor: Schinzel R; Department of Molecular and Cell Biology, The University of California, Berkeley, Li Ka Shing Center for Biomedical and Health Sciences, USA., Dillin A; Department of Molecular and Cell Biology, The University of California, Berkeley, Li Ka Shing Center for Biomedical and Health Sciences, USA; Howard Hughes Medical Institute, The University of California, Berkeley, USA. Electronic address: dillin@berkeley.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2015 Apr; Vol. 33, pp. 102-10. Date of Electronic Publication: 2015 Feb 09.
DOI: 10.1016/j.ceb.2015.01.006
Abstrakt: Organisms have to cope with an unpredictable and dynamic environment. It is crucial for any living being to respond to these changes by buffering the effects on cellular homeostasis. Failure to appropriately respond to stress can have severe consequences for health and survival. Eukaryotic cells possess several organelle-specific stress responses to cope with this challenge. Besides their central role in stress resistance, these pathways have also been shown to be important in the regulation of proteome maintenance, development and longevity. Intriguingly, many of these effects seem to be controlled by only a subset of cells implying a systemic regulation in a cell non-autonomous manner. The understanding of the nature of this stress communication across tissues, its mechanisms and impact, will be paramount in understanding disease etiology and the development of therapeutic strategies.
(Copyright © 2015. Published by Elsevier Ltd.)
Databáze: MEDLINE
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