Helical tomotherapy in head and neck cancer: a European single-center experience.

Autor:	Van Gestel D; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium dirk.vangestel@zna.be., Van den Weyngaert D; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., De Kerf G; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., De Ost B; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Vanderveken O; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Van Laer C; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Specenier P; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Geussens Y; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Wouters K; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Meulemans E; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Cheung KJ; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Grégoire V; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium., Vermorken JB; Department of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium; Department of Otolaryngology and Head and Neck Surgery, Department of Medical Oncology, Scientific Coordination and Biostatistics, and Data-Management Multidisciplinair Oncologisch Centrum Antwerpen, Antwerp University Hospital, Edegem, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Iridium Kankernetwerk, Campus Nikolaas, Sint Niklaas, Belgium; Radiation Oncology Department and Centre for Molecular Imaging and Experimental Radiotherapy, St-Luc University Hospital, Brussels, Belgium.
Jazyk:	angličtina
Zdroj:	The oncologist [Oncologist] 2015 Mar; Vol. 20 (3), pp. 279-90. Date of Electronic Publication: 2015 Feb 11.
DOI:	10.1634/theoncologist.2014-0337
Abstrakt:	Background: We report on a retrospective analysis of 147 patients with early and locoregionally advanced squamous cell head and neck cancer (SCCHN) treated with helical tomotherapy (HT). Patients and Methods: Included were patients with SCCHN of the oral cavity (OC), oropharynx (OP), hypopharynx (HP), or larynx (L) consecutively treated in one radiotherapy center in 2008 and 2009. The prescribed HT dose was 60-66 Gy in the postoperative setting (group A) and 66-70 Gy when given as primary treatment (group B). HT was given alone, concurrent with systemic therapy (ST), that is, chemotherapy, biotherapy, or both, and with or without induction therapy (IT). Acute and late toxicities are reported using standard criteria; locoregional failure/progression (LRF), distant metastases (DM), and second primary tumors (SPT) were documented, and event-free survival (EFS) and overall survival (OS) were calculated from the start of HT. Results: Group A patients received HT alone in 22 cases and HT + ST in 20 cases; group B patients received HT alone in 17 cases and HT + ST in 88 cases. Severe (grade ≥ 3) acute mucosal toxicity and swallowing problems increased with more additional ST. After a median follow-up of 44 months, grade ≥2 late toxicity after HT + ST was approximately twice that of HT alone for skin, subcutis, pharynx, and larynx. Forty percent had grade ≥2 late xerostomia, and 29% had mucosal toxicity. At 3 years, LRF/DM/SPT occurred in 7%/7%/17% and 25%/13%/5% in groups A and B, respectively, leading to a 3-year EFS/OS of 64%/74% and 56%/63% in groups A and B, respectively. Conclusion: The use of HT alone or in combination with ST is feasible and promising and has a low late fatality rate. However, late toxicity is nearly twice as high when ST is added to HT. (©AlphaMed Press.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text