Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia.

Autor: Karlsson IK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bennet AM; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Ploner A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Andersson TM; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Reynolds CA; Department of Psychology, University of California-Riverside, Riverside, CA, USA., Gatz M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA, USA. Electronic address: Nancy.Pedersen@ki.se.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2015 Apr; Vol. 36 (4), pp. 1751-1756. Date of Electronic Publication: 2015 Jan 14.
DOI: 10.1016/j.neurobiolaging.2015.01.008
Abstrakt: To investigate how apolipoprotein E (APOE) affects the temporal relationship between depression and dementia, we conducted a nested case-control study with longitudinal depression and dementia evaluations from several population studies by using 804 dementia cases and 1600 matched controls, totaling 1519 unique individuals. Depression within 10 years of onset of dementia was strongly associated with dementia diagnosis regardless of APOE status (incidence rate ratio [IRR] 5.25, 95% confidence interval [95% CI] 3.32-8.31 for ε4 carriers, IRR 4.40, 95%CI 3.23-5.99 for noncarriers). However, we found a significant interaction between depression more than 10 years before the onset of dementia and APOE (p = 0.01), with depression more distal to dementia being a risk factor only in ε4 carriers (IRR 3.39, 95% CI 1.69-6.78 for carriers, IRR 1.01, 95% CI 0.60-1.70 for noncarriers). Thus, depression with onset close in time to dementia onset is associated with disease irrespective of APOE genotype, whereas depression more distal to dementia onset is a risk factor only in ε4-carriers. This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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