| Autor: |
Kayanakis JG; Clinique cardiologique Paulmy, Bayonne., Larouchi L, Doat P, Grenet B, Fauvel JM, Bounhoure JP |
| Jazyk: |
francouzština |
| Zdroj: |
Presse medicale (Paris, France : 1983) [Presse Med] 1989 Apr 01; Vol. 18 (13), pp. 667-70. |
| Abstrakt: |
Xamoterol, a partial agonist of beta 1-adrenoceptors, was tested as a cardiotonic drug in 10 patients with moderate chronic heart failure. The trial was double-blind drug versus placebo for 3 months and open for one year. At 3 months the patients were clinically improved with downgrading by one NYHA class, and there was a significant increase in response to a 36-second exercise, as compared with the placebo group. Haemodynamic index, a 14 per cent fall in pulmonary wedge pressure and a 7 per cent increase in left ventricular stroke work as compared with the placebo group. This clinical and haemodynamic improvement was paralleled by a reduction of the double product on exercise. In long term use, xamoterol did not seem to induce tachyphylaxis, and few side-effects were recorded during this trial. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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