Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration.

Autor: Silva RO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Damasceno SR; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Silva IS; Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil., Silva VG; Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil., Brito CF; Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil., Teixeira AÉ; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Nunes GB; Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil., Camara CA; Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE, Brazil., Filho JM; Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil., Gutierrez SJ; Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI, Brazil., Ribeiro RA; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Souza MH; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Barbosa AL; Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil., Freitas RM; Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil., Medeiros JV; Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil. Electronic address: jandvenes@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Chemico-biological interactions [Chem Biol Interact] 2015 Mar 05; Vol. 229, pp. 55-63. Date of Electronic Publication: 2015 Feb 03.
DOI: 10.1016/j.cbi.2015.01.029
Abstrakt: Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.
(Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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