The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation.

Autor:	Zhou K; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: K.Zhou@umcg.nl., Ferdous M; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., de Boer RF; Certe Laboratory for Infectious Diseases, Groningen, The Netherlands., Kooistra-Smid AM; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Certe Laboratory for Infectious Diseases, Groningen, The Netherlands., Grundmann H; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Friedrich AW; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: Alex.Friedrich@umcg.nl., Rossen JW; University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2015 May; Vol. 21 (5), pp. 468.e7-18. Date of Electronic Publication: 2014 Dec 27.
DOI:	10.1016/j.cmi.2014.12.009
Abstrakt:	Shiga toxin-producing Escherichia coli (STEC) O104:H4 emerged as an important pathogen when it caused a large outbreak in Germany in 2011. Little is known about the evolutionary history and genomic diversity of the bacterium. The current communication describes a comprehensive analysis of STEC O104:H4 genomes from the 2011 outbreak and other non-outbreak-related isolates. Outbreak-related isolates formed a tight cluster that shared a monophyletic relation with two non-outbreak clusters, suggesting that all three clusters originated from a common ancestor. Eight single nucleotide polymorphisms, seven of which were non-synonymous, distinguished outbreak from non-outbreak isolates. Lineage-specific markers indicated that recent partitions were driven by selective pressures associated with niche adaptation. Based on the results, an evolutionary model for STEC O104:H4 is proposed. Our analysis provides the evolutionary context at population level and describes the emergence of clones with novel properties, which is necessary for developing comprehensive approaches to early warning and control. (Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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