| Autor: |
Craig JC; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143., Torkelson SM, Findell PR, Weiner RI |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1989 May; Vol. 32 (5), pp. 961-8. |
| DOI: |
10.1021/jm00125a007 |
| Abstrakt: |
A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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